They had a problem with rejections during guiding, would they be fine even if ML has no me...

It because the seme already know from all his own notes lol and what do u mean brought up? As in the people saying it? Or narrative wise? Because seme did point out that his mark is throbbing because of uke thinking of him on the set ahahaha

Yeah, but what about it now? They're linked through it even if they're not a match? And even if the ML has all the notes, the feelings aren't there. He needsnto accept him to not feel the rejection

Yeah no, I agree, I'm not talking about the rejection because yeah that would be still a problem unless seme feel like opening up but I'm just answering your second paragraph about the mark and yes they are still link, like how the seme can still feel it when the uke think of him (in recent chapter seme mention his mark bother him), the difference (and why it didn't get brought up) is just at the start they obv don't know each other which is why seme immediately obsessed to uke when seme found out the mark but this situation is different because seme already know from the notes, seme just being difficult because of his personality LOL can't imagine himself opening up to someone, it's actually pretty funny to see him reacting to his past self being clingy ahahahahaha

--- I'm sorry this is just me rambling ----
Also the whole thing about the experiment is questionable..... Like u say they have a mark, that in itself is already a variable to the experiment (especially if the doctor just gonna let them go after this)..... Because people that share marks will always feel a connection with each other, whether it's romantic or not, so it really won't be difficult for them to be want to pair again even if it's not romantic ╮(￣▽￣)╭ I guess I can see the doctor gambling on seme personality to reject uke but that's like a very low chance..... I suppose either results would still be a results .......but still I don't see what would he do next? It's not like he can try out the uke with the other espers, I mean he can, he just need to keep threatening them, not do what he promise and with seme "leash" with the crazy guide, they basically can't kill the guide without risking seme getting out of control (〜￣△￣)〜 Unless that's what the doctor planned

Not out of the picture, that Doctor seems to be too knee deep in whatever he's researching, he might as well gamble the entire world if he must.