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Reading all these comments made me wonder if Little A's memory is not the most reliable source. He remembers Fluffy as a big black dog and his uncle as a burly bearded man but clearly the present time varies differently. And well, men shave but Kendrick's memory of Big A also depicts him as a completely different man.
So while I do hope that Fluffy is not actually a dog converted into a hybrid. This does put up the question as to why his cognitive function seems less human than the others. This shows two possibilities, either he's actually a dog, OR that after a certain threshold the person affected with the virus of hybridization gradually loses their humanity.
I did consider if he was just on some spectrum but that does not explain the barking and licking and his protective stance being akeen to a dog's. Another proof of this is Milton's growing urge to be milked and bred by a bull. And Kendrick's possessiveness over his eggs when he's out of his mind.
Sure, Fluffy's behaviour could be credited to him being a dog hybrid, but still man, something's fishy