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This story is called "Dysfunctional family therapy" for a reason, and so I guess it's living up to it's name.
Sentarou's life was sad because he lived as someone's shadows by becoming their ghostwriter, never gaining recognition for his own work and later ended up becoming unemployed and doing a job that he doesn't like.
Since his childhood, Touma never had anything he could call a happy family. His youth was wasted on his family's dirty dealings and later on, jail.
Also Meguru literally gets isolated by her pre-school friends. Isolation is a form of bullying. She also gets teased a lot for having no mother and father. Getting misunderstood by same age kids must be traumatic for her at such a young age, even though she hides it well in her expression.
Her mother was probably the most happy person in the whole world. Giving birth to a kid and never taking responsibility of her. Travelling the world before she dies while she left her child to the child's grandmother.
Meguru grew up not knowing what a mother's warmth and love feels like because her mother was so focused on herself. At her mother's own funeral, she had no expression, instead she was scared of being alone when she grabbed her grandma's hand. Her mother had the happiest life out of all of them. She was carefree, fickle, irresponsible, indecisive, remorse-less, she was so selfish she did whatever she wanted without even caring about her closed ones...I also didn't like Shouji (the child's actual father) that much.
Despite all of this, the three of them found a sense of belonging among each other. Because Sentarou and Touma have given up on their dreams or hope, they ended up finding comfort in an innocent child that was just as hurt as them. All of them hid their pain behind a mask of indifference.
So the title makes sense in a way I guess...