The saddest scene you've ever watch..

There is many sad anime scene that make me cry like Gin disappeared from Harubi no Mori e or koro sensei died from assasination classroom. No doubt it is so sad that from watching the AMV alone make me cried so hard that my eyes got all puffy.
Since anime gave more feeling since there is motion and sound that some time I want to cry so hard that I almost screamed out my heart content or my head aching from holding cry coz there is someone else around.

So... what is your saddest anime scene that never failed yo make you cry??.. And why??(=・ω・=)