
Well I don't know if their O/B/A. Rule apply here, but they're pretty similar, but basic rule is that after a while the mark needs to be bitten again to strengthen their bond, so for a good while it will be sort whacked out, but over time, with the help that the main two have a deeper connection, the bite can become inactive or just a small tingle, nothing significant like vomiting or intense shaking.

What I get from their last talk is that he would not become sick if they do it during the no heat period.
So, if they want to have fun and are not looking for a baby, they would be alright.
That's sad if everytime they want to have sex, the uke throw up... Huhuhuhuhu so tragic...
Or that's just once?? Still don't know ╮( ̄▽ ̄)╭