Responses

They are related like gods are related though, I think that's different from family as we define it. Osiris is his brother, but Isis is also Osiris sister who gave birth to Horus.
Spoiler probably.
Horus has two kids and one is with Hathor his wife. In some myths Hathor is Horus' mother, her name translates to House of Horus, I'm expecting a "we aren't actually related storyline".
"i like you uncle seth" listen, i know they've always been related, but he DID NOT HAVE TO ACKNOWLEDGE THAT