The uncle took him home to live with him after the attempted murder, and one assumes raised him to adulthood, and ran the house of prostitution. Sakura at some point decided to work there (due to his damage in associating sex with being needed and being thanked). The uncle didn't like it and told him to quit, but I guess as an adult, Sakura had the right to make that decision. The uncle was protective, especially re stalker. Now that Sakura is in a healthy relationship, the uncle probably bought another business and the big pigtails guy and Sakura are going to work there as whatever the heck Nyan Pros do. :)
Okay...that sounds clear enough...but what about the his big reveal in the last part (the bathtub scene)
You mean that he doesn't have a weenie? Transgender.
Yup, that part....okay, I though I'm the only one thinking that uncle is a trans
What a sweet ending...but I'm confused with the uncle's part