Responses
She has the old king’s soul not his blood so none of her kids will be affected by the illness.
The crimson dragons descendants suffer from this disease because they have his blood. It's passed down. But Yona won't have something like that because she isn't the crimson dragon by blood. She is the crimson dragon because she is the reincarnation of the originals soul. Not blood. So her ancestors won't suffer the same fate because she isn't connected to the original crimson dragon by blood.

but damn the story of the previous generation was so passionate.
Also, this is just a theory but I guess Yona will...
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decide not to have any children. the children of the Crimson King all succumb to illness - if she has children its gonna be like the previous generation repeat again...